Interaction between Dramamine and Dramamine Less Drowsy: There is no known interaction between Dramamine and Dramamine Less Drowsy in our records. However, an interaction may still exist. Always consult your doctor before taking these medications together. Do not stop taking the medications without a physician's advice. Compare Dramamine vs Meclizine head-to-head for uses, ratings, cost, side effects, interactions and more. Dramamine rated 9.3/10 vs Meclizine rated 7.6/10 in overall patient satisfaction. Dramamine rated 9.3/10 vs Meclizine rated 7.6/10 in overall patient satisfaction. Because even Less Drowsy Formula of Dramamine left me feeling too drowsy, I asked my Dr. about alternatives and he prescribed the patch. We used them on our recent 14 day cruise and I felt like they did indeed leave me feeling less drowsy than the Dramamine. Dramamine® All Day Less Drowsy relieves motion sickness symptoms with less drowsiness for up to 24 hours: Long-lasting formula Treats and prevents nausea, dizziness, vomiting & queasiness (Note: Dramamine does make a chewable pill, as well as a less drowsy pill that contains the same active ingredient as Bonine.) In terms of pricing, Bonine is generally more expensive. Dramamine is dimenhydrinate and is sedating. Bonine and Dramamine Less Drowsy are meclizine and are typically nonsedating. If you want to be up and around meclizine is a good choice. Choose the Dramamine® product that's right for you. Motion sickness can affect many travelers, so find out which product is right for you. That way, you’ll be all set to prevent motion sickness before it ruins your ride. Best Answer: Dramamine II (or non-drowsy Dramamine) is generically called meclizine and has a much less sedating effect than the regular Dramamine, which is a different drug and will make you drowsy. Compare Dramamine vs. Dramamine II, which is better for uses like: Nausea, Motion Sickness and Dizziness. Compare head-to-head ratings, side effects, warnings, dosages, interactions and patient reviews.